SCIEX introduces new accurate mass instrument, the ZenoTOF 7600 system

20-07-2021

SCIEX introduces the ZenoTOF 7600 system, a new accurate mass LC-MS/MS system as it allows scientists to characterize, identify, and quantify molecules better than ever before by generating data that has been previously unattainable. This innovation will unravel real analytical challenges and help advance the development of new precision diagnostics and biotherapeutics.
Zeno trap and EAD. An extraordinary combination of unparalleled MS/MS sensitivity and a step-change in fragmentation technology. Together they deliver the ability to acquire key MS/MS features needed to:
1.    Characterize large molecules including post-translational modifications
2.    Elucidate positional isomers on lipids and small molecules
3.    Identify and quantify peptides and proteins at unparalleled speed


ZenoTOF 7600 has the ability to:
1.    Overcome QTOF MS/MS duty cycle deficiencies
a.    >90% ions injected into the TOF.
b.    Sensitivity gains of up to 5-20X with Zeno trap pulsing.
c.    Identify and quantify low abundance species
2.    Tunable fragmentation of all molecule types
a.    Utilize controlled electron activated dissociation (EAD)
3.    MS/MS scan rates of up to 133Hz
a.    Improved DDA and High resolution MRMHR


Electron activated dissociation (EAD)
EAD allows for a range of free electron-based fragmentation mechanisms within one instrument. The ability to tune electron kinetic energy within an EAD experiment expand the utility of the approach to all molecules type from singly charged small molecules to large multiply charged proteins.


Zeno trap
Ions are accumulated in the Zeno trap right before being pulsed rapidly into the TOF, meaning we can detect up to 20x more ions. Consequently, each TOF experiment contains more useful MS/MS data, particularly on lower abundance species that were previously undetectable, introducing you to a new sensitivity revolution.

 

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