Multiroom incubator for embryo culture
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6 independent chambers preventing cross contamination
Esco MIRI Multiroom Incubator
The MIRI® has six (6) chambers which are completely independent of each other. This is ideal because any disruption (e.g. temperature drop after opening the lid) has zero impact on the rest of the system. Furthermore, calibration is so much simpler because there is no crossover of heat from adjacent chambers.
Temperature regulation is thus completely independent per chamber. The MIRI® features a total of twelve (12) temperature controlled points. That is two (2) points for every chamber: one on the bottom and another on the heated lid. The heated lid is another great feature of the MIRI® as it prevents condensation and enhances temperature uniformity across cultured dishes.
Six-Chamber Independent Isolation
The technical architecture of the MIRI incubator is based on six separate chambers, each serving as an isolated micro-environment. This isolation is critical for individualized embryo culture, as it prevents "cross-talk" between patient samples. When an embryologist accesses one chamber, the gas and temperature levels in the remaining five chambers remain completely undisturbed. This ensures a steady-state environment that is vital for minimizing metabolic stress during the sensitive stages of embryonic cleavage.
Dual-Heating System with Heated Lids
Each of the six chambers is equipped with a dual-heating system that warms both the bottom and the lid. Technically, the heated lid is essential because it prevents condensation from forming on the top of the culture dish. By keeping the lid at a slightly higher temperature than the base, the system ensures high thermal uniformity and clear visibility for microscopic assessment. This top-and-bottom heating approach ensures that embryos are encased in a stable thermal field, mimicking physiological conditions.
High-Precision Infrared (IR) CO2 Sensors
For precise atmospheric control, the incubator utilizes advanced Infrared sensors to measure CO2 levels. Unlike thermal conductivity sensors, IR sensors are technically superior because they are not affected by fluctuations in humidity or temperature. This allows the system to maintain a very tight tolerance for carbon dioxide concentration, which is fundamental for maintaining the bicarbonate buffer system of the culture media and ensuring a stable pH for embryo development.
Hypoxic Culture Capability and Oxygen Control
The MIRI incubator is technically optimized for tri-gas or hypoxic culture. It features a built-in gas mixer that allows for the precise reduction of CO2 levels, typically to 5 %, to better reflect the natural environment of the female reproductive tract. This hypoxic condition is regulated by medical-grade oxygen sensors that provide real-time feedback to the microprocessor. Reducing oxygen levels is a proven technical method for decreasing oxidative stress and improving the quality of the developing blastocysts.
Rapid Recovery of Gas and Temperature Parameters
One of the most important technical metrics for any incubator is the speed at which it recovers after a door opening. The MIRI is engineered for exceptionally fast recovery times. Once a chamber lid is closed, the system uses high-flow valves and powerful heaters to return to the programmed CO2, O2, and temperature setpoints within minutes. This rapid stabilization is crucial for maintaining the continuity of the culture environment throughout the busy laboratory day.
Integrated Validation Ports for External QC
To support laboratory quality control (QC), each of the six chambers features a dedicated validation port. These ports allow embryologists to connect external gas and temperature validation devices to independently verify the internal conditions. This technical feature ensures that the incubator can be calibrated and validated without disturbing the embryos or the internal sensors. It provides an extra layer of security and supports compliance with international laboratory accreditation standards.
Compact Footprint and Space Optimization
The incubator is designed as a benchtop unit with a small physical footprint, making it ideal for laboratories with limited space. Despite its compact size, it provides high capacity with six independent rooms. Technically, the design emphasizes ergonomic access, allowing for easy placement and retrieval of dishes. Its stackable design also allows clinics to increase their incubation capacity without requiring additional bench space, providing a scalable solution for growing practices.
Microprocessor Control and Comprehensive Alarms
The entire system is managed by a sophisticated microprocessor that continuously monitors all internal parameters. An intuitive digital interface displays real-time data for each chamber. The unit is equipped with a comprehensive alarm suite that provides audible and visual alerts for temperature deviations, gas concentration shifts, or gas supply failures. This technical oversight ensures that any potential issues are detected immediately, safeguarding the integrity of the cultures at all times.
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