Shimadzu LCMS-2050 Single Quadrupole Mass Spectrometer Header

Introducing the **NEW** High-Performance Liquid Chromatograph Mass Spectrometer LCMS-2050



- Seamless integration with LC by design
- Superior detection for added confidence
- Streamlined operation for cost efficiency

The LCMS-2050 single quadrupole mass spectrometer combines the user-friendliness of an LC detector with the excellent performance of MS to provide a complete package of easy to use high-level performance and compactness. To make it accessible to all users, the system is enhanced with technology and functions to ensure that even technicians unfamiliar with mass spectrometers can easily and efficiently perform analysis. While delivering operational convenience on par with an LC detector, the LCMS-2050 provides the high speed, high sensitivity, and wide mass range that are the hallmarks of Shimadzu mass spectrometers. Capable of analyzing a wide range of compounds from high to low polarity, the LCMS-2050 can be used in a variety of markets and applications. This new mass spectrometer system is also equipped with data analysis features using Analytical Intelligence and eco conscious functions, which contribute to labor and energy savings in the laboratory.


Seamless integration with LC by design
Compact for LC Systems

The LCMS-2050 is designed to be the same width and stackable with other Shimadzu Nexera series LC components, so additional bench space is not required. It can be integrated seamlessly with the Nexera series, i-Series, legacy model HPLC systems, and also with the Nexera Prep preparative system.

Easy Parameter Settings for Simplified Operation

Mass spectrometers are often considered difficult to use, but the advanced engineering of the LCMS-2050 makes it as simple to use as other LC detectors. Only the most basic of acquisition parameters are required to obtain reliable and sensitive detection


Superior detection for added confidence
Measures a Wide Range of Compounds

A heated dual ion source (DUIS), which combines the features of electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) is the LCMS-2050’s standard ionization source, enabling compounds with a wide range of characteristics to be analyzed simultaneously. Heated DUIS includes both an ESI spray nozzle and an APCI corona needle, making it possible to detect both high and low polarity molecules in a single run. In the example below, high-polarity Simetryn is detected, as well as the low-polarity Quintozene, which is difficult to detect by ESI alone.


Biopolymer Analysis

With an m/z range of 2 to 2,000, the LCMS-2050 is capable of analyzing large biopolymers. Multiple charge states are produced by ESI ionization of biomolecules such as peptides, proteins, and oligonucleotides, making the LCMS-2050 suitable for the characterization of these compounds. A mass spectrum of Nusinersen, an antisense oligonucleotide with a molecular weight of 7127 u, is shown below. Five different multi-charged states were detected by the wide mass range of the LCMS-2050, enabling accurate deconvolution using LabSolutions Multi-charged ion analysis software. The molecular weight was determined excellent accuracy

High-Speed MS Suitable for UHPLC

High-speed MS data sampling is required for high-speed analysis by UHPLC. High-speed performance is a hallmark of Shimadzu LCMS detectors, and the LCMS-2050 is no exception. The LCMS-2050 provides the world’s fastest performance, with a scan speed of 15,000 u/sec and a positive/negative ion switching speed of 10 msec. Thanks to the sufficient sampling rate, the instrument reliably captures sharp UHPLC peaks. At slower scan speeds (7,500 and 10,000 u/sec), data points are insufficient, so the peaks are either lost or insufficiently separated. If the scan speed is fast (15,000 u/sec), sufficient data points are ensured, so the peaks are sharp, and their separation is good.


Streamlined operation for cost efficiency
Space Savings

The LCMS-2050 is similar in size and stackable with LC units so it can be added without the need for additional space.

Automatic Checks of Instrument Status

Mass spectrometer calibration and calibration checks for mass accuracy, resolution, and intensity can be performed automatically using the System Check function. The calibration standard is injected through an independent ESI spray source, and re-calibration can be automatically initiated if required, resulting in consistent data acquisition and laboratory operation without the need of user intervention. Calibration report outputs ensure traceability of instrument status.

Environmental Responsibility

Thanks to its small size, its single-phase 100 to 240 V specifications, and its Ecology Mode function, the LCMS-2050 achieves energy savings of 43% in comparison with the LCMS-2020. It is also recognized as an Eco Product Plus under Shimadzu's proprietary environmentally friendly product recognition system. The system not only limits running costs during analysis, but contributes to realizing a carbon-free society by limiting CO2 emissions.

Easy Maintenance

Like all other MS products by Shimadzu, the ionization interface of the LCMS-2050 has a simple, accessible design that minimizes the effort needed to maintain the instrument. The desolvation line (DL) that transfers the sample into the vacuum chamber can be replaced without using tools and without breaking vacuum. Quick and easy maintenance means less downtime, labor, and cost.


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