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Shimadzu MALDI-8030


Dual-Polarity Benchtop Linear MALDI-TOF Mass Spectrometer

Shimadzu releases the new MALDI-8030 MALDI-TOF Mass Spectrometer


What is MALDI?

MALDI is the abbreviation for "Matrix Assisted Laser Desorption/Ionization." The sample for MALDI is uniformly mixed in a large quantity of matrix. The matrix absorbs the ultraviolet light (nitrogen laser light, wavelength 337 nm) and converts it to heat energy. A small part of the matrix (down to 100 nm from the top outer surface of the Analyte in the diagram) heats rapidly (in several nano seconds) and is vaporized, together with the sample.


What is TOF MS?

TOF MS is the abbreviation for Time of Flight Mass Spectrometry. Charged ions of various sizes are generated on the sample slide, as shown in the diagram. A potential difference V0 between the sample slide and ground attracts the ions in the direction shown in the diagram. The velocity of the attracted ions v is determined by the law of conservation of energy. As the potential difference V0 is constant with respect to all ions, ions with smaller m/z value (lighter ions) and more highly charged ions move faster through the drift space until they reach the detector. Consequently, the time of ion flight differs according to the mass-to-charge ratio (m/z) value of the ion. The method of mass spectrometry that exploits this phenomenon is called Time of Flight Mass Spectrometry.



Affordable Class-leading Workhorse

The MALDI-8030 is the latest in a long line of MALDI-TOF products from Shimadzu. Instrument performance specifications is extended from those of the MALDI-8020 to cater for compounds best suited to analysis in negative ion mode. This dual-polarity, benchtop linear MALDI-TOF mass spectrometer delivers outstanding performance in a compact footprint, making it an ideal choice for today’s increasingly demanding laboratories.

Key features:

- Dual mode (positive/negative ion) MALDI-TOF
- 200 Hz solid-state laser, 355 nm
- Load-lock chamber for fast sample introduction
- UV laser-based source cleaning (patented)
- Flexibility
- Small footprint/benchtop design
- Quiet operation (<55 dB)


Best-in-class sensitivity and resolution

Dual mode instruments have traditionally been the instruments of choice in MALDI-TOF-based quality control (QC) and profiling workflows, and the MALDI-8030 is no exception. Peptides, proteins, polymers or oligonucleotides - the instrument is capable of delivering the performance required for QC applications. Research laboratories will also benefit from the MS capabilities of the instrument through the rapid mass-measurement of samples.


Sample target solutions

Compatible with the FlexiMass series of microscope slide-format sample targets, these slides provide researchers with options depending on their experimental workflow. The individually barcoded, single-use FlexiMass-DS slides provide a convenient solution for more routine or defined workflows. Ready-to-use, these disposable targets eliminate the need for cleaning and the risk of carryover. Alternatively, the reusable stainless steel FlexiMass-SR sample targets provide a cost-effective, longer-term solution to sample preparation.


TrueClean automated source cleaning

To maintain instrument performance over time, the MALDI-8030 features wide-bore ion optics - a feature used on our existing MALDI-TOF products - which minimize the risk of source contamination over time, providing a robust platform. To maximize uptime, the system is equipped with TrueClean - an automated, rapid (<10 min) UV laser-based source cleaning which can be used to clean the extraction electrode in-situ without breaking instrument vacuum.


Quality as standard

Through the selection of components demonstrating improved longevity and performance, and by reducing the number of component parts, our engineers have created a reliable and robust platform capable of delivering outstanding performance in a small footprint. The MALDI systems are maintained by trained service support engineers who form part of the Shimadzu global distribution and support network. Routine maintenance is simplified thanks to the instrument design, providing our engineers with easy access to commonly serviced parts.

Data management and integrity

 Operating under the control of MALDI Solutions™ software, the software features a centralized, secure Microsoft® SQL database which can be used to store everything from sample lists and acquisition Parameter Sets to acquired MALDI data. The system is managed by an Administrator and customizable user profiles provide control over access to the database and operation of the instrument.


Read more about Shimadzu MALDI-8030