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MIRI® II Multiroom Incubator
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Stable culture environment
Esco MIRI II Multiroom Incubator
MIRI® II Multiroom Incubator dedicates one chamber for one patient to ultimately secure a minimum-stress environment for embryos. The chambers are completely independent of each other. Any disruption on one chamber (e.g. temperature drop after opening the lid) has zero impact on the rest of the system, this allowe embryologist to culture embryos from individual patients in individual chambers.
The heated Lid prevents condensation and improves temperature regulation and recovery enhancing uniformity within each chamber. The heated bottom provides direct heat transfer to the culture dishes for stable heat regulation.
There is also the touchscreen PC that allows user to control and monitor important parameters (temperature, gas concentration) simultaneously and gives visual and audible alarm to signal critical conditions. It has large display that can be easily seen from a distance.
Six-Chamber Independent Isolation Architecture
The defining technical characteristic of the MIRI II is its six independent chambers. Each chamber is physically and functionally separated, allowing the laboratory to dedicate a specific room to a single patient. This isolation prevents environmental disturbances from affecting multiple samples. When a single chamber is opened, only that specific micro-environment undergoes a recovery cycle, while the remaining five chambers maintain absolute stability in temperature and gas concentration.
Advanced Tri-Gas Mixing and Regulation
The incubator features an integrated gas mixer that precisely regulates CO2 and O2 concentrations. This allows for the creation of a hypoxic environment, typically maintaining O2 at 5 % to mimic physiological conditions. The system uses high-precision sensors to monitor the gas levels constantly. If a deviation occurs, the microprocessor-controlled valves adjust the flow immediately, ensuring the gas setpoints are maintained within very tight tolerances for consistent media pH.
Dual-Heating System with Heated Lids
Thermal uniformity is maintained through a dual-heating mechanism where both the chamber base and the lid are heated. The heated lids are technically essential to prevent condensation on the top of culture dishes, which ensures clear visualization and prevents changes in osmolarity. This top-and-bottom heating approach ensures that the culture dishes are enveloped in a uniform temperature field, eliminating cold spots and providing rapid thermal recovery after access.
High-Performance IR and Chemical Sensors
To ensure atmospheric accuracy, the MIRI II utilizes advanced NDIR (Non-Dispersive Infrared) sensors for CO2 measurement and medical-grade sensors for O2. These sensors are chosen for their high sensitivity and stability over time. The IR sensor is particularly important as it is not affected by temperature or humidity fluctuations, providing a reliable reading of the carbon dioxide levels which directly govern the bicarbonate buffering system of the culture media.
Integrated Validation Ports for Quality Control
Each of the six chambers is equipped with a dedicated validation port. This allows embryologists to connect external gas and temperature validation devices to verify the internal chamber conditions independently. Technically, this supports laboratory accreditation and quality management by providing a way to perform routine calibrations and checks without disrupting the sterile environment or the ongoing culture process.
Rapid Parameter Recovery Technology
One of the most critical technical metrics for an IVF incubator is recovery time. The MIRI II is engineered to return to gas and temperature setpoints within minutes of a chamber being closed. This is achieved through high-flow gas valves and powerful heating elements managed by a fast-acting control algorithm. Reducing the duration of environmental fluctuations is vital for preventing metabolic stress and maintaining the developmental competence of the embryos.
Touchscreen Interface and Data Logging
The incubator is operated via a high-resolution touchscreen interface that provides real-time data for all six chambers simultaneously. This interface allows for easy programming of setpoints and alarm limits. Technically, the system includes internal data logging, recording every parameter deviation and door opening event. This data can be exported for audit trails, ensuring full traceability of the incubation conditions for every patient cycle.
Compact Design and Benchtop Efficiency
The MIRI II is designed as a benchtop unit with a small footprint, providing six independent rooms without requiring excessive laboratory space. The technical layout emphasizes ergonomic access to each chamber, and the materials used are chosen for their ease of decontamination. This compact yet powerful design allows clinics to maximize their incubation capacity while maintaining the highest standards of individualized care for each embryo.
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