LC-MS Solvents

Scharlau LC-MS grade solvents are engineered to address the specific technical challenges of liquid chromatography coupled with mass spectrometry. Unlike standard HPLC reagents, LC-MS solvents must exhibit exceptionally low levels of inorganic and organic impurities that could lead to background noise or chemical interference. These solvents are characterized by a chemical assay typically exceeding 99.9% and are strictly controlled for trace metal ions, such as sodium and potassium, which are known to form unwanted adducts in the ion source. 

The technical integrity of these solvents is further guaranteed through advanced purification and filtration processes. Every batch is microfiltered through membranes with a pore diameter of 0.1mum for UHPLC-MS or 0.22mum for LC-MS to remove particulate matter that could clog capillary tubes or damage mass spectrometer components. Additionally, Scharlau performs specialized suitability tests, including the Reserpine test, to ensure the absence of persistent ghost peaks and to maintain a stable baseline.